Methotrexate (MTX) Induced Pancytopenia - A Rare Serious Adverse Effect

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Methotrexate Induced Pancytopenia

The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become proble...

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Pancytopenia and interstitial pneumonitis are one of the most serious and unpredictable adverse effects of low dose, pulse methotrexate (MTX) in treating rheumatoid arthritis (RA). It is important to investigate the historical, clinical or immunologic features associated with the development of such toxicity, in order to use MTX more appropriately. Two hundred eighty four patients (female 230 m...

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ژورنال

عنوان ژورنال: Journal of Evolution of Medical and Dental Sciences

سال: 2020

ISSN: 2278-4748,2278-4802

DOI: 10.14260/jemds/2020/604